A dishonest person is bound to meet with setbacks sooner or later.

不老实的人非碰钉子不可。

They are rarely allowed to try and solve problems, meet with setbacks and failure.

他们很少会有机会允许去尝试，去解决问题，遇到挫折和失败。

While half of the subjects experienced field meet with setbacks, coupled with their loved ones die, mentally and physically exhausted so he turned to enthusiasm for Buddhism.

而经历了半生的科场蹭蹬，加之至亲离世，身心疲惫使得他开始转向了对佛学的热情。