There won't be a sudden break, just a gradual increase in pain until it becomes quite severe.

这不是突然产生的，而是逐渐增加的疼痛直到变得相当严重。

But as long as the change is gradual, it shouldn't entail too much pain for the U.S..

不过，只要这种变化时渐进的，就不会对美国带来很大痛苦。

RESULTS: The major clinical manifestations of the 3 cases of CMCJ included gradual enlargement of the jaw, paresthesia, pain and repeated bleeding.

结果：3例颌骨中心性黏液表皮样癌临床主要表现为颌骨内渐进性增大的肿块，有感觉异常、疼痛和反复出血。